Daily brain nutrition to achieve an optimal state of mind.
- One shot. 22 capsules' worth of functional ingredients.
- Higher absorption than pills
Lipinova® SPMs and turmeric extract turn down inflammation in your body and support a healthy inflammatory response. The result is mental clarity.
Why it matters:
Inflammation that never fully resolves is linked to brain fog, slower recovery between training sessions, and cognitive decline over time. Resolving it is what actually restores clarity.
Every day your brain cells take oxidative damage from stress and high output. CoQ10 helps protect brain cells from oxidative damage and supports the mitochondria that power your neurons.
Why it matters:
Mitochondria are what power every thought and every rep. Protecting them from oxidative damage is what keeps mental energy and output from declining as daily stress adds up.
Your brain is built to adapt, grow, and rewire at any age. Lion's Mane supports nerve growth factor, citicoline rebuilds neural membranes and sharpens focus, and B12 supports the myelin that keeps brain signals fast.
Why it matters:
The brain's ability to adapt and rewire is what lets you keep learning, growing, and recovering mentally.
The best formula is worthless if it never reaches your brain. NuSomes™ nano-encapsulation wraps every ingredient to survive digestion and cross into circulation. Our bioavailability study results show: 5.3x more omega-3, 11.8x more CoQ10, 62x more turmeric absorbed than standard forms.
The average Americans' omega-3 index levels falls 50% short of optimal
This means that our brains lack essential fats needed to properly recover and function.
Sources
Powers CD, Sternberg MR, Mineva EM, et al. "Over half of the United States population had an undesirably low Omega-3 Index based on erythrocyte membrane measurements: results from the cross-sectional NHANES from August 2021 to August 2023." Curr Dev Nutr 2026;10(6):107715. doi:10.1016/j.cdnut.2026.107715 (n=7,213; adult mean 4.25%).
The 8% mark comes from Harris WS & von Schacky C, Prev Med 2004;39(1):212–220, where it was defined in relation to coronary heart disease risk. It is the reference point researchers use for omega-3 status; it was not established as a cognitive or athletic performance target.
Only 1 in 4 US adults reach optimal levels through their diet.
The standard american diet lacks enough fatty fish, and the human body poorly converts plant based omega-3s.
Sources
Seafood: Ansai N, Terry AL, Stierman B, Ahluwalia N. "Seafood consumption among youth and adults: United States, August 2021–August 2023." NCHS Data Brief No. 538, 2025 — 24.3% of adults aged 20+ ate seafood twice a week or more. Recommendation: Dietary Guidelines for Americans 2020–2025, at least 8 ounce-equivalents of seafood per week.
Intake: Cave C, Hein N, Smith LM, et al. Nutrients 2020;12(7):2045. NHANES 2003–2014, n=44,585 — average daily EPA+DHA intake approximately 100 mg.
STATE takes care of your daily omega-3 intake.
One shot of STATE carries 187.5 mg of EPA + DHA that absorbs like 990mg omega-3s. Meaning up to 5.3× increase in absorption with our NuSomes™ technology.
Sources
These are two different measurements and they do not share an axis. The bars on the left are intake — milligrams swallowed. The figure on the right is blood exposure — the softgel dose you would have to take to reach the same level in circulation. An absorbed-equivalent figure is inferred from fold-change; it is not an established clinical dose and should never be compared directly against an intake recommendation.
Absorption: NuSome™ omega-3 5.3× total exposure (AUC) vs. the same oil in a softgel, 6.2× on EPA. n=10 crossover. Nulixir human studies, data on file.
Average US adult intake ~100 mg/day EPA+DHA: Cave C, Hein N, Smith LM, et al. Nutrients 2020;12(7):2045 (NHANES 2003–2014, n=44,585). 250 mg/day is the EFSA adequate intake. Standard softgel = 1,000 mg fish oil delivering ~300 mg EPA+DHA (NIH Office of Dietary Supplements). VITAL and ASCEND both used 840 mg/day EPA+DHA and were null for their primary endpoints.
Powered by Lipinova®, the most advanced omega-3 ingredient on the market.
Clinical studies show Lipinova® supplementation increases SPM (Specialized Pro-resolving Mediators) levels in the bloodstream. SPMs are the signal your body uses to actually resolve inflammation after impact.
- Without resolution support · inflammation lingers
- With SPM-rich omega-3s · resolves to baseline
Why this matters
For contact-sport athletes, repeated hits mean repeated inflammation. Left unresolved, that inflammation is linked to lasting damage to brain tissue.
Sources
Souza PR, Marques RM, Gomez EA, et al. “Enriched marine oil supplements increase peripheral blood specialized pro-resolving mediator concentrations and reprogram host immune responses: a randomized double-blind placebo-controlled study.” Circ Res 2020;126(1):75–90. doi:10.1161/CIRCRESAHA.119.315506 (n=22, crossover, acute biomarker endpoints).
Independent replication: Al-Shaer AE, Regan J, Buddenbaum N, et al. J Nutr 2022;152(7):1783–1791. Mechanism review: Serhan CN. “Pro-resolving lipid mediators are leads for resolution physiology.” Nature 2014;510:92–101.
What this evidence does and does not show. It shows that oral SPM-enriched marine oil raises SPM levels in blood and changes immune-cell behaviour in small human studies. It does not show a clinical outcome; no adequately powered placebo-controlled outcome trial has been published. LIPINOVA® supplies SPM precursors, not resolvins, protectins or maresins themselves.
Omega-3 Reduces Neurological Damage in NCAA Football Athletes.
Read More
Researchers tracked two college football teams across a full 131-day season, measuring Nf-L — a protein that leaks into the blood when nerve fibers take damage. One team took high-dose omega-3 (2,000mg DHA + 560mg EPA + 320mg DPA, 4+ times a week); the other didn't.
After camp, the non-supplemented team's Nf-L climbed ~1.5x above baseline and stayed there all season. The omega-3 team's didn't move.
- Control
- Omega-3
Control group
Nf-L levels rose ~1.5× after pre-season camp and stayed elevated all season.
Omega-3 group
No meaningful change recorded.
View the data
| Timepoint | Control | Omega-3 | Between-group |
|---|---|---|---|
| T1 · Baseline | +0% | +0% | ns |
| T2 · Post-camp | +51.5% | +4.8% | p<.001 |
| T3 · In-season | +41.5% | +9.2% | p=.002 |
| T4 · In-season | +39.3% | +6.4% | p=.005 |
| T5 · In-season | +50.2% | +12.2% | ns |
| T6 · In-season | +47% | +11% | ns |
Why this matters
Nf-L is a protein that leaks into the blood when nerve fibres are damaged. More hits, more Nf-L.
Sources
Heileson JL, Anzalone AJ, Carbuhn AF, et al. “The effect of omega-3 fatty acids on a biomarker of head trauma in NCAA football athletes: a multi-site, non-randomized study.” J Int Soc Sports Nutr 2021;18(1):65. doi:10.1186/s12970-021-00461-1
Design: multi-site, non-randomized, no placebo. Supplement group (NCAA Division I) received 2,000 mg DHA + 560 mg EPA + 320 mg DPA at least 4×/week across a 131-day season; control group was NCAA Division III.
Effect sizes: control group d = 0.59–0.85 vs. baseline; omega-3 group d = 0.11–0.23 vs. baseline; group × time interaction p = .024.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The Evidence Dashboard
The research behind STATE. Scan the counts, see the outcomes, and judge the proof for yourself.
| Ingredient | Human clinical papers | Outcomes measured | Common findings |
|---|---|---|---|
| Omega-3 EPA & DHA | 5,127 | Omega-3 Index, red-cell and plasma EPA/DHA, triglycerides, inflammatory markers, neurofilament light | Raises the Omega-3 Index and blood EPA/DHA reliably and dose-dependently, supports a healthy inflammatory response, and rebuilds omega-3 status in the 97.6% of US adults — and 0 of 702 tested college football players — who fall below the 8% benchmark.1,2,3 |
| SPM precursors | 44 | Plasma SPM and precursor concentrations, monocyte and macrophage phagocytosis, resolution-phase markers | Raises circulating SPM levels and increases immune-cell phagocytosis versus placebo, supporting the body's natural resolution phase after inflammatory stress. Independently replicated.4,5 |
| Citicoline | 157 | Attention errors, psychomotor and processing speed, episodic and composite memory, brain phospholipid turnover | Placebo-controlled trials at 250–500 mg report fewer attention errors, faster psychomotor speed, and stronger episodic and composite memory, with benefits building over 28 days to 12 weeks.6,7,8 |
| Lion's Mane extract | 7 | Cognitive rating scales (HDS-R, MMSE), Stroop and reaction-time tasks, subjective stress and mood | Human trials report higher cognitive-scale scores, faster processing speed on attention tasks, and lower subjective stress, with a well-tolerated safety profile across studies running 4 to 49 weeks.9,10,11 |
| Turmeric root extract | 601 | CRP, IL-6, TNF-α, oxidative stress markers, joint comfort, working memory and mood | Consistently reduces circulating inflammatory markers including CRP, IL-6 and TNF-α, and supports joint comfort. Well-absorbed forms additionally report gains in working memory and mood — absorption is the variable that separates the positive trials from the rest.12,13,14 |
| CoQ10 | 710 | Plasma CoQ10, oxidative stress markers, subjective fatigue, exercise performance, migraine frequency | Raises plasma CoQ10 dependably and supports mitochondrial energy production, with reduced subjective fatigue, better maintained exercise performance and lower oxidative stress reported in placebo-controlled trials. Results track absorbed CoQ10, not milligrams on the label.15,21 |
| Vitamin B12 | 1,717 | Serum B12, methylmalonic acid, homocysteine, fatigue and energy scales, brain atrophy rate | Restores B12 status and lowers homocysteine dependably — 500 mcg/day cut methylmalonic acid by 33% in a dose-ranging trial — supporting normal energy metabolism and nervous-system function. Benefits are strongest in people with low baseline status.16,17 |
| Vitamin B6 | 1,057 | Plasma pyridoxal-5′-phosphate, homocysteine, mood and fatigue scales | Raises plasma PLP — the active coenzyme form — steeply and dose-dependently. PLP is the cofactor the body uses to build dopamine, serotonin and GABA, and it works alongside B12 to support normal homocysteine and energy-yielding metabolism.18,19 |
Ingredient-level generalization from publicly available human clinical studies indexed on PubMed. Counts are per-ingredient and may overlap where one trial tested more than one ingredient. Outcomes vary by dose, form, duration and population, and evidence for an ingredient is not evidence for a finished product.
References
- Powers CD et al. Curr Dev Nutr 2026;10(6):107715.
- Anzalone A, Carbuhn A et al. J Athl Train 2019;54(1):7–11.
- Ritz PP et al. PLOS ONE 2020;15(4):e0228834.
- Souza PR et al. Circ Res 2020;126(1):75–90.
- Al-Shaer AE et al. J Nutr 2022.
- McGlade E et al. J Atten Disord 2019;23(2):121–134.
- Nakazaki E et al. J Nutr 2021;151(8):2153–2160.
- EFSA NDA Panel. EFSA J 2024;22(7):e8861.
- Mori K et al. Phytother Res 2009;23(3):367–72.
- Li IC et al. Front Aging Neurosci 2020;12:155.
- Docherty S et al. Nutrients 2023;15(22):4842.
- Small GW et al. Am J Geriatr Psychiatry 2018;26(3):266–277.
- Cox KHM et al. Nutrients 2020;12(6):1678.
- Ringman JM et al. Alzheimers Res Ther 2012;4(5):43.
- Mizuno K et al. Nutrition 2008;24(4):293–9.
- Eussen SJPM et al. Arch Intern Med 2005;165(10):1167–72.
- Shoffel-Havakuk H et al. JAMA Otolaryngol Head Neck Surg 2021;147(1):9–15.
- Smith AD et al. PLoS One 2010;5(9):e12244.
- Malouf R, Grimley Evans J. Cochrane Database Syst Rev 2003;(4):CD004393.
- Clarke R et al. Am J Clin Nutr 2014;100(2):657–66.
- Sándor PS et al. Neurology 2005;64(4):713–5.